Amy L. Ryan PhD
Dr. Ryan is an Associate Professor in Anatomy and Cell Biology and has co-directed the Center for Gene Therapy for CF with Dr. Engelhardt for the past 3 years. Dr. Ryan has served on the CF Foundations stem cell consortium for the past 7 years and brings innovation to the center in pluripotent stem cell models of tissue development in humans with research focused on airway, intestine, and pancreatic development. She has also developed the first ferret pluripotent stem cells which have potential application in pre-clinical models of autologous cell therapy. Her research program also develops and applies more complex 3D and tissue level models, including organ-on-chip technology, to study the impact of the cellular niche on stem cell function. Dr. Ryan will lead the Precision Medicine Center for CF capitalizing on the significant strengths and innovations in CF research at Iowa.
| University of Iowa | Stead Family Scholars: Role of the Pathogenic Stem Cell Niche in Regulating Airway Stem Cell Attrition |
NIH/NIDDK DK054759 Pilot | Targeting the exocrine pancreas to restore function in Cystic Fibrosis-Related Diabetes |
| CFF RYAN22XX0 | High throughput screening to maintain pluripotent ferret iPSC for use in pre-clinical autologous cell therapy models |
| NSF/2225554 | RECODE: Defining Environmental Design criteria for Directed Differentiation of Type 1 from Type 2 Lung Alveolar Epithelial Cells |
| NIH/NHLBI/R01HL153622 | Quantitative analysis of mucociliary clearance in airway ciliopathies |
| CFF RYAN21XX0 | Epigenetic dysregulation of airway basal cells by the inflammatory microenvironment |
| NIH/NIDDKP30 DK054759 | Center for Gene Therapy of Cystic Fibrosis |
