Research Spotlight
Dr. John F. Engelhardt research focuses on the molecular basis of CF and the development of gene therapies for the disease. Notably, Dr. Engelhardt's laboratory was the first to clone ferrets, creating new animal models that have enhanced the study of CF pathologies and potential treatments.
Research Papers
Durable transgene expression and efficient re-administration after rAAV2.5T-mediated fCFTRDR gene delivery to adult ferret lungs by Yinghua Tang - Anatomy and Cell Biolgy
Pilot Programs
Pilot programs provides seed money for research that has not yet reached the stage of maturity necessary for funding by traditional NIH mechanisms such as RO1s and PO1s. Such research ideas should be considered innovative and may potentially be high risk.
Latest Publications
Considerations for early life genetic therapies in cystic fibrosis
Wednesday, April 29, 2026
Cystic fibrosis (CF) is caused by mutations in the gene encoding for the CF transmembrane conductance regulator (CFTR) anion channel. Since the initial characterization of CF in the early 20^(th) century, advances in clinical management have reduced disease burden and increased longevity. These advances are amplified by the recent development of highly effective CFTR modulator therapies (HEMT) that provided remarkable clinical results in people with CF (pwCF). However, some pwCF do not benefit...
News
University of Iowa physician–scientist receives prestigious Lasker Award
Thursday, September 11, 2025
