Tracheal

Research Spotlight

Dr. John F. Engelhardt research focuses on the molecular basis of CF and the development of gene therapies for the disease. Notably, Dr. Engelhardt's laboratory was the first to clone ferrets, creating new animal models that have enhanced the study of CF pathologies and potential treatments.

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Research Papers

Durable transgene expression and efficient re-administration after rAAV2.5T-mediated fCFTRDR gene delivery to adult ferret lungs by Yinghua Tang - Anatomy and Cell Biolgy

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Pilot Programs

Pilot programs  provides seed money for research that has not yet reached the stage of maturity necessary for funding by traditional NIH mechanisms such as RO1s and PO1s. Such research ideas should be considered innovative and may potentially be high risk.

Latest Publications

Theratyping as a tool to guide clinical decision-making in patients with suspected cystic fibrosis and variants currently ineligible for CFTR modulator therapy

Saturday, November 15, 2025
Ryan M Gannon
The combination of elexacaftor/tezacaftor/ivacaftor (ETI) is effective in people with cystic fibrosis (CF) with at least one F508del-CFTR allele; however, approximately 10% have variants without established ETI responsiveness and are ineligible for therapy. Additionally, diagnostic confirmation or exclusion of CF can be challenging in individuals with compatible symptoms, CFTR variants of unknown significance, and indeterminate sweat chloride or nasal potential difference (NPD) results. We...

Events

ACB Seminar Series - Dr. Pierre Coulombe promotional image

ACB Seminar Series - Dr. Pierre Coulombe

Wednesday, February 11, 2026 9:30am to 10:30am
Bowen Science Building

Dr. Pierre Coulombe, Professor and Chair of the Department of Cell and Developmental Biology from the University of Michigan, will present a seminar titled "Sequential Expression of Keratins Regulate Progenitor and Differentiating Keratinocytes in Healthy and Diseased Skin."

PhD Dissertation Seminar: "Novel roles for Heat Shock Factor 1 (HSF1) in gene expression in C. elegans" promotional image

PhD Dissertation Seminar: "Novel roles for Heat Shock Factor 1 (HSF1) in gene expression in C. elegans"

Thursday, February 12, 2026 11:30am
Biology Building East
Sehee Min, a PhD candidate in the Integrated Biology (iBio) Graduate Program, will be defending her dissertation on Thursday, February 12, at 11:30am in Room 401, Biology Building East (BBE).
Biology Seminar: "Oxidative stress, lipid damage, and mitochondrial dysfunction may potentiate epilepsy and autism" promotional image

Biology Seminar: "Oxidative stress, lipid damage, and mitochondrial dysfunction may potentiate epilepsy and autism"

Friday, February 13, 2026 3:30pm
Biology Building East
The Department of Biology’s seminar speaker on Friday, February 13, is from our own department, John Manak. His seminar will be held at 3:30pm in Kollros Auditorium (Room 101), Biology Building East (BBE).
ACB Seminar Series - Raji Shyam promotional image

ACB Seminar Series - Raji Shyam

Wednesday, February 18, 2026 9:30am to 10:30am
Bowen Science Building

Dr. Raji Shyam, an Assistant Professor of Anatomy and Cell Biology will present a seminar titled "The Effects of Cell Extrinsic Factors on Corneal Endothelium."

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ACB Seminar Series - Patrick Link promotional image

ACB Seminar Series - Patrick Link

Wednesday, February 25, 2026 9:30am to 10:30am
Bowen Science Building

Dr. Patrick Link, an Assistant Professor of Biomedical Engineering will present a seminar titled "Myeloperoxidase Promotes Pulmonary Fibrosis by Inhibiting Cathepsin K to Bias the Lung Toward ECM Accumulation."

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