Dr. Randak’s research focuses on the molecular mechanisms of CFTR and other ATP-binding cassette (ABC) transporter functions so that novel approaches to treating ABC protein-related diseases can be developed. He is particularly interested in mechanisms, structural basis, and physiologic role of CFTR adenylate kinase activity. Using transgenic mice expressing adenylate kinase deficient CFTR in the intestine, his group investigates the role of CFTR adenylate kinase activity for channel function in the intestinal epithelium and in cholera toxin induced increased intestinal fluid secretion. Most recently, he investigates the role of adenylate kinase dependent CFTR gating in bicarbonate secretion under the Center’s pilot program. Dr. Randak also directs the Electrophysiology Core in the CFF RDP.