Tracheal

Research Spotlight

Amy Ryan, Associate Professor in Anatomy and Cell Biology and Internal Medicine, Director of the P30 funded Precision Medicine Center for CF and Vice Chair for Research In Anatomy and Cell Biology

Latest Publications

Theratyping as a tool to guide clinical decision-making in patients with suspected cystic fibrosis and variants currently ineligible for CFTR modulator therapy

Saturday, November 15, 2025
Ryan M Gannon
The combination of elexacaftor/tezacaftor/ivacaftor (ETI) is effective in people with cystic fibrosis (CF) with at least one F508del-CFTR allele; however, approximately 10% have variants without established ETI responsiveness and are ineligible for therapy. Additionally, diagnostic confirmation or exclusion of CF can be challenging in individuals with compatible symptoms, CFTR variants of unknown significance, and indeterminate sweat chloride or nasal potential difference (NPD) results. We...

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